The Mississippi Delta AVA, a grape growing region that stretches across the states of Mississippi and Louisiana, also extends into the southwestern portion of Tennessee.

Given the state's humid climate, French hybrid grapes are widely cultivated or their resistance to fungal diseases. Grape varieties include Cabernet Sauvignon, Gewürztraminer, Catawba, Niagra, Chambourcin, Traminette and many others.

In addition, the production of fruit wines is on the rise, as producers continue to experiment with ingredients including blackberries, peaches, strawberries, blueberries, and apples.

However, as far as grape wine goes, the state is home to approximately 45 wineries, many of which are small producers that farm five acres (of the approximately 700 acres of vineyards in the state). Though today the region is home to numerous producers, Tennessee's post-prohibition wine industry came into being practically overnight. In fact, from 1995 to 2005 the number of wineries in the state doubled.

The state is divided into three wine making regions: West, Central, and East. However, most of the wineries are located in the Central and Eastern regions. As wine producers continue crafting quality wines, wine tourism is expected to expand. For now, wine tour hot-spots primarily centralize around Nashville and other major cities across the state.